Sialic Acid in Lipoproteins with a Special Reference to Low Density Lipoproteins

This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. acid content of LDL and lipoprotein metabolism in combined hyperlipidemia and primary moderate hypercholesterolemia. acid content of LDL and its relation to lipid concentrations and metabolism of LDL and cholesterol. Submitted. increases the sialic acid content of LDL in hypercholesterolemic patients. Atherosclerosis. In press. 8 ABBREVIATIONS AMI acute myocardial infarction ANOVA analysis of variance apo apolipoprotein Asn asparagine BMI body mass index BMDP BioMedical Data Program CAD coronary artery disease CE cholesterol ester CETP cholesterol ester transfer protein CM chylomicron CMR chylomicron remnant d density DM diabetes mellitus FCHL familial combined hyperlipidemia FCR fractional catabolic rate FFA free fatty acids FH familial hypercholesterolemia HDL high density lipoprotein HL hepatic lipase HMG-CoA 3-hydroxy-3-methylglutaryl coenzyme A IDL intermediate density lipoprotein LCAT lecithin:cholesterol acyltransferase LDL low density lipoprotein Lp(a) lipoprotein(a) LPL lipoprotein lipase PLTP phospholipid transfer protein TG triglyceride TR transport rate TSA total sialic acid VLDL very low density lipoprotein 9 1 INTRODUCTION